Nuclear Architecture

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Science, Volume 345 no. 6202 pp. 1240-1241, 12 September 2014
John Rinn, Mitchell Guttman, RNA and dynamic nuclear organization

Cutaway of the nucleus highlighting three organizational levels: active and inactive regions, and nuclear bodies. Clockwise from right to left: The nucleolus is formed around actively transcribed rRNA sites; paraspeckles are formed by the Neat1 lncRNA; the Malat1 lncRNA is present within the nuclear speckle, and actively transcribed genes are repositioned close to nuclear speckles; the inactive X chromosome (Barr body) is coated by the Xist lncRNA and dynamically repositioned from the active to inactive compartments where it is localized to the periphery of the nucleus; lncRNAs can mediate gene-gene interactions across chromosomes and within chromosomes.

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Nuclear Architecture

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