Unlocking the Epigenome in Ewing Sarcoma

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Cancer Cell, November 10, 2014, Volume 26, Issue 5

Ewing sarcoma is a pediatric bone tumor driven by the EWS-FLI1 translocation. The cover illustrates the finding of Riggi et al. (pp. 668–681) on how EWS-FLI1 induces or represses enhancer elements depending on the DNA sequence at each binding site: binding of EWS-FLI1 to GGAA repeats opens chromatin to create enhancers that activate oncogenic pathways, whereas binding of EWS-FLI1 at single GGAA sites represses enhancers.

Illustrator and Photoshop.

Unlocking the Epigenome in Ewing Sarcoma

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