Cancer Cell, November 10, 2014, Volume 26, Issue 5
Ewing sarcoma is a pediatric bone tumor driven by the EWS-FLI1 translocation. The cover illustrates the finding of Riggi et al. (pp. 668–681) on how EWS-FLI1 induces or represses enhancer elements depending on the DNA sequence at each binding site: binding of EWS-FLI1 to GGAA repeats opens chromatin to create enhancers that activate oncogenic pathways, whereas binding of EWS-FLI1 at single GGAA sites represses enhancers.
Nature Medicine, May 2018 Volume 24, Issue 5 Diffuse midline gliomas (DMGs) with the histone H3 K27M mutation are fatal pediatric tumors. In this issue, Michelle Monje and colleagues report […]
Cover proposal for Cell October 2017 The image in form of a mandala is a representation of diverse tissue and organs that are involved in immune response to vaccination forming […]