Xist lncRNA

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Science, Volume 314 no 6147, 16 August 2013
Jesse Engreitz, The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome

“Upon activation, Xist spreads from its genomic locus to sites in close three-dimensional proximity. Xist modifies chromatin architecture at these sites, thereby repositioning these regions into the Xist compartment (red cloud) and pulling new regions (green, yellow) of the chromosome into closer proximity. These structural changes allow Xist to access new sites and spread across the entire chromosome.”

Illustrator.

Xist lncRNA

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